Novel 6-aryl-7-alkyl/aryl-[1,2,4]triazolo[4,3-a][1,3,5]triazine-5(6H)-thiones, processes for their preparation, characterization and evaluation of their in vitro antioxidant activity

ABSTRACT. A series of nine new 6-aryl-7-alkyl/aryl-[1,2,4]triazolo[4,3-a][1,3,5]triazine-5(6H)-thiones (2a-i) were synthesized by a reaction N-triazol-3-yl imidates (1) with three different isothiocyanate derivatives (RNCS) in refluxing toluene. The structures the final heterocyclic compounds confirmed 1H-NMR, 13C-NMR, FT-IR, elemental analysis, and mass spectral analysis. target vitro screened for their activity as antioxidants using DPPH (2,2?-diphenyl-1-picrylhydrazyl) FRAP (ferric reducing/antioxidant power) methods. results revealed that some triazolotriazine-5-(6H)thiones exhibited antioxidant ranging from moderate to high. obtained findings (2g, 2h, 2i) have superiority among all compounds, It is obvious presence hydroxyl group structure essential properties should be taken into consideration further design potential properties.
 
 KEY WORDS: Imidates, Isothiocyanates, Antioxidant, Triazole, DPPH, FRAP
 Bull. Chem. Soc. Ethiop. 2021, 35(3), 565-572.
 DOI: https://dx.doi.org/10.4314/bcse.v35i3.8